<turbo-stream action="append" target="news"><template>  <div class="row mb-4 py-2 news-box">
  <div class="col-12 col-md-8 col-lg-9 order-md-1 order-2">
    <div class="news-box__info-line mb-2">
        <span class="me-2 new badge text-danger bg-red-100">
          Negative
        </span>
        <div class="me-2"><a class="text-gray" data-turbo-frame="_top" href="/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004">Ionis Pharmaceuticals, Inc.</a></div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">Reuters</div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">about 2 months ago</div>
    </div>

    <div class="mb-2">
      <a target="_blank" rel="nofollow" href="https://www.reuters.com/business/healthcare-pharmaceuticals/ionis-novartis-key-experimental-heart-drug-fails-late-stage-trial-2026-09-04/">Ionis, Novartis&#39; key experimental heart drug fails in late-stage trial</a>
    </div>

      <div class="me-0 me-md-5">
        Ionis Pharmaceuticals and partner Novartis&#39; experimental drug to lower ​high levels of a cholesterol-carrying particle ‌in heart patients failed in a late-stage trial, the companies said on Friday.
      </div>
  </div>

  <div class="col-12 col-md-4 col-lg-3 order-md-2 order-1">
  </div>
</div>

  <div class="row mb-4 py-2 news-box">
  <div class="col-12 col-md-8 col-lg-9 order-md-1 order-2">
    <div class="news-box__info-line mb-2">
        <span class="me-2 new badge text-secondary bg-gray-200">
          Neutral
        </span>
        <div class="me-2"><a class="text-gray" data-turbo-frame="_top" href="/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004">Ionis Pharmaceuticals, Inc.</a></div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">Business Wire</div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">about 2 months ago</div>
    </div>

    <div class="mb-2">
      <a target="_blank" rel="nofollow" href="https://www.businesswire.com/news/home/20260904799979/en/Ionis-partner-Novartis-announces-Lp-a-HORIZON-Phase-3-topline-results-for-pelacarsen-in-patients-with-elevated-Lp-a-and-established-cardiovascular-disease-CVD/">Ionis partner Novartis announces Lp(a)HORIZON Phase 3 topline results for pelacarsen in patients with elevated Lp(a) and established cardiovascular disease (CVD)</a>
    </div>

      <div class="me-0 me-md-5">
        CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) partner Novartis today announced that the pelacarsen Phase 3 Lp(a)HORIZON study, a pioneering cardiovascular outcomes trial, did not meet its primary endpoint of reducing the risk of cardiovascular events, a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and urgent coronary revas...
      </div>
  </div>

  <div class="col-12 col-md-4 col-lg-3 order-md-2 order-1">
  </div>
</div>

  <div class="row mb-4 py-2 news-box">
  <div class="col-12 col-md-8 col-lg-9 order-md-1 order-2">
    <div class="news-box__info-line mb-2">
        <span class="me-2 new badge text-success bg-green-100">
          Positive
        </span>
        <div class="me-2"><a class="text-gray" data-turbo-frame="_top" href="/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004">Ionis Pharmaceuticals, Inc.</a></div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">Barrons</div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">about 2 months ago</div>
    </div>

    <div class="mb-2">
      <a target="_blank" rel="nofollow" href="https://www.barrons.com/articles/ionis-stock-fda-zanvastro-9865d3d7">This Biotech Wins a Big FDA Approval. Why Wall Street Is Shrugging.</a>
    </div>

      <div class="me-0 me-md-5">
        Ionis Pharmaceuticals wins regulatory clearance for its quarterly injection, Zanvastro, in Alexander disease. Analysts are focused elsewhere.
      </div>
  </div>

  <div class="col-12 col-md-4 col-lg-3 order-md-2 order-1">
  </div>
</div>

  <div class="row mb-4 py-2 news-box">
  <div class="col-12 col-md-8 col-lg-9 order-md-1 order-2">
    <div class="news-box__info-line mb-2">
        <span class="me-2 new badge text-secondary bg-gray-200">
          Neutral
        </span>
        <div class="me-2"><a class="text-gray" data-turbo-frame="_top" href="/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004">Ionis Pharmaceuticals, Inc.</a></div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">Business Wire</div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">about 2 months ago</div>
    </div>

    <div class="mb-2">
      <a target="_blank" rel="nofollow" href="https://www.businesswire.com/news/home/20260903826844/en/ZANVASTRO%E2%84%A2-zilganersen-approved-by-the-FDA-as-the-first-and-only-disease-modifying-treatment-for-Alexander-disease-AxD-in-pediatric-and-adult-patients/">ZANVASTRO™ (zilganersen) approved by the FDA as the first and only disease modifying treatment for Alexander disease (AxD) in pediatric and adult patients</a>
    </div>

      <div class="me-0 me-md-5">
        CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that the U.S. Food and Drug Administration (FDA) has approved ZANVASTRO™ (zilganersen) for the treatment of Alexander disease (AxD) in pediatric and adult patients. ZANVASTRO is the first and only disease modifying treatment for AxD, an ultra-rare, progressive and often fatal neurological disorder that...
      </div>
  </div>

  <div class="col-12 col-md-4 col-lg-3 order-md-2 order-1">
  </div>
</div>

  <div class="row mb-4 py-2 news-box">
  <div class="col-12 col-md-8 col-lg-9 order-md-1 order-2">
    <div class="news-box__info-line mb-2">
        <span class="me-2 new badge text-success bg-green-100">
          Positive
        </span>
        <div class="me-2"><a class="text-gray" data-turbo-frame="_top" href="/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004">Ionis Pharmaceuticals, Inc.</a></div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">Reuters</div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">about 2 months ago</div>
    </div>

    <div class="mb-2">
      <a target="_blank" rel="nofollow" href="https://www.reuters.com/legal/litigation/us-fda-approves-ionis-pharmas-therapy-treat-rare-brain-disorder-2026-09-03/">US FDA approves Ionis Pharma&#39;s therapy to treat rare brain disorder</a>
    </div>

      <div class="me-0 me-md-5">
        The ​U.S. FDA on Thursday approved Ionis Pharmaceuticals&#39; ‌therapy to treat a rare disease that affects the brain&#39;s white matter, making it the ​first treatment to get ​the nod for the genetic disorder.
      </div>
  </div>

  <div class="col-12 col-md-4 col-lg-3 order-md-2 order-1">
  </div>
</div>

  <div class="row mb-4 py-2 news-box">
  <div class="col-12 col-md-8 col-lg-9 order-md-1 order-2">
    <div class="news-box__info-line mb-2">
        <span class="me-2 new badge text-secondary bg-gray-200">
          Neutral
        </span>
        <div class="me-2"><a class="text-gray" data-turbo-frame="_top" href="/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004">Ionis Pharmaceuticals, Inc.</a></div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">Business Wire</div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">2 months ago</div>
    </div>

    <div class="mb-2">
      <a target="_blank" rel="nofollow" href="https://www.businesswire.com/news/home/20260808352745/en/IONS-Investors-Have-Opportunity-to-Join-Ionis-Pharmaceuticals-Inc.-Fraud-Investigation-with-SBS-Law/">IONS Investors Have Opportunity to Join Ionis Pharmaceuticals, Inc. Fraud Investigation with SBS Law</a>
    </div>

      <div class="me-0 me-md-5">
        LOS ANGELES--(BUSINESS WIRE)---- $IONS--IONS Investors Have Opportunity to Join Ionis Pharmaceuticals, Inc. Fraud Investigation with SBS Law.
      </div>
  </div>

  <div class="col-12 col-md-4 col-lg-3 order-md-2 order-1">
  </div>
</div>

  <div class="row mb-4 py-2 news-box">
  <div class="col-12 col-md-8 col-lg-9 order-md-1 order-2">
    <div class="news-box__info-line mb-2">
        <div class="me-2"><a class="text-gray" data-turbo-frame="_top" href="/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004">Ionis Pharmaceuticals, Inc.</a></div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 news-box__source-badge">
          <img class="news-box__source-logo" alt="StocksGuide" src="https://stocksguide.com/assets/logos/stocks_guide-94bb1add.svg" />
        </div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">3 months ago</div>
    </div>

    <div class="mb-2">
      <a data-turbo-frame="_top" href="https://stocksguide.com/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004#earnings-events-section">Ionis Pharmaceuticals, Inc. Q2 2026 Earnings Call Transcript and Presentation available</a>
    </div>

      <a data-controller="earnings-news-cta" data-earnings-news-cta-event-id-value="4539580" data-action="click-&gt;earnings-news-cta#open" data-turbo-frame="_top" class="btn btn-outline-primary btn--small border-0 mt-0 px-2" href="https://stocksguide.com/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004?earnings_event_id=4539580">
        Show summary
        <i class="fa fa-arrow-right fa-fw"></i>
</a>  </div>

  <div class="col-12 col-md-4 col-lg-3 order-md-2 order-1">
      <a data-turbo-frame="_top" href="https://stocksguide.com/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004#earnings-events-section">
        <div class="news-box__logo-frame mb-3 mb-md-0">
          <img class="news-box__logo" alt="Ionis Pharmaceuticals, Inc." src="https://stocksguide.com/rails/active_storage/blobs/proxy/eyJfcmFpbHMiOnsiZGF0YSI6MTc1NTAsInB1ciI6ImJsb2JfaWQifX0=--ca0f73f357021af249d2577f4bc7a66c853b1a80/Ionis-Pharmaceuticals-Inc-US4622221004.png" />
          <span class="news-box__logo-label">Earnings Call Transcript</span>
        </div>
</a>  </div>
</div>

  <div class="row mb-4 py-2 news-box">
  <div class="col-12 col-md-8 col-lg-9 order-md-1 order-2">
    <div class="news-box__info-line mb-2">
        <span class="me-2 new badge text-secondary bg-gray-200">
          Neutral
        </span>
        <div class="me-2"><a class="text-gray" data-turbo-frame="_top" href="/en/stock/Ionis-Pharmaceuticals-Inc-US4622221004">Ionis Pharmaceuticals, Inc.</a></div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">Business Wire</div>
        <div class="me-2 text-gray text-size-10">●</div>
        <div class="me-2 text-gray">3 months ago</div>
    </div>

    <div class="mb-2">
      <a target="_blank" rel="nofollow" href="https://www.businesswire.com/news/home/20260729107077/en/Ionis-announces-Dr.-Frank-Bennett-chief-scientific-officer-to-retire/">Ionis announces Dr. Frank Bennett, chief scientific officer, to retire</a>
    </div>

      <div class="me-0 me-md-5">
        CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) announced today that Frank Bennett, Ph.D., executive vice president and chief scientific officer, will retire effective February 2027.“As a founding scientist, Frank has been instrumental in shaping Ionis and advancing the entire field of RNA-targeted medicines,” said Brett P. Monia, Ph.D., chief executive officer, Io...
      </div>
  </div>

  <div class="col-12 col-md-4 col-lg-3 order-md-2 order-1">
  </div>
</div>

</template></turbo-stream><turbo-stream action="replace" target="link"><template><div id="link">
    <a class="btn btn-outline-primary btn--small" data-turbo-stream="" href="/en/news/Ionis-Pharmaceuticals-Inc-US4622221004/load_more?page=3">
      Show more News
      <i class="fa fa-arrow-down fa-fw"></i>
</a></div>
</template></turbo-stream>