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          Negative
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        <div class="me-2"><a class="text-gray" data-turbo-frame="_top" href="/en/stock/Aeglea-BioTherapeutics-Inc-US00773J1034">Aeglea BioTherapeutics Inc</a></div>
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      <a target="_blank" rel="nofollow" href="https://www.investors.com/news/technology/spyre-therapeutics-rheumatoid-arthritis-failure/">Spyre Plunges, While This Setback Isn&#39;t Shaking Analysts</a>
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        Spyre Therapeutics took a hit Wednesday after its experimental rheumatoid arthritis treatment failed to pass muster in midstage testing.
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        <div class="me-2 text-gray">3 months ago</div>
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      <a target="_blank" rel="nofollow" href="https://www.globenewswire.com/news-release/2026/08/25/3350866/0/en/spyre-therapeutics-announces-topline-results-from-the-rheumatoid-arthritis-sub-study-of-the-skyway-phase-2-trial-of-spy072.html">Spyre Therapeutics Announces Topline Results from the Rheumatoid Arthritis Sub-study of the SKYWAY Phase 2 Trial of SPY072</a>
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      <div class="me-0 me-md-5">
        Both doses of SPY072 demonstrated statistically significant benefits compared to placebo on one or more of the primary (change from baseline in DAS28-CRP), key secondary (ACR20), and exploratory endpoints (e.g., ACR50)
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        <div class="me-2 text-gray">3 months ago</div>
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      <a target="_blank" rel="nofollow" href="https://www.globenewswire.com/news-release/2026/08/07/3341387/0/en/spyre-therapeutics-announces-grants-of-inducement-awards.html">Spyre Therapeutics Announces Grants of Inducement Awards</a>
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        WALTHAM, Mass., Aug. 07, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that Spyre&#39;s indepen...
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        <div class="me-2 text-gray">3 months ago</div>
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      <a target="_blank" rel="nofollow" href="https://www.globenewswire.com/news-release/2026/08/04/3338788/0/en/Spyre-Therapeutics-Reports-Second-Quarter-2026-Financial-Results-and-Provides-Corporate-Update.html">Spyre Therapeutics Reports Second Quarter 2026 Financial Results and Provides Corporate Update</a>
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        Announced positive topline induction data for SPY001 and SPY002 from Part A of the Phase 2 SKYLINE trial (“SKYLINE”), demonstrating best-in-class efficacy potential and a safety profile consistent with in-class comparators
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        <div class="me-2 text-gray">4 months ago</div>
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      <a target="_blank" rel="nofollow" href="https://www.globenewswire.com/news-release/2026/07/02/3321558/0/en/Spyre-Therapeutics-Announces-Grants-of-Inducement-Awards.html">Spyre Therapeutics Announces Grants of Inducement Awards</a>
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        WALTHAM, Mass., July 02, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients, today announced that Spyre&#39;s indepen...
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        <div class="me-2 text-gray">5 months ago</div>
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      <a target="_blank" rel="nofollow" href="https://www.etftrends.com/etf-building-blocks-content-hub/biotech-etf-index-surges-10-rebalance/">Biotech ETF Index Surges 10% After Rebalance</a>
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        After a sweeping semi-annual rebalance, the biotech index underlying the ALPS Medical Breakthroughs ETF (SBIO) gained over 10% in just six trading days beginning June 18. Key Takeaways: SBIO&#39;s underlying index gained 10.01% in six trading days following its June 18 semi-annual rebalance.
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        <div class="me-2 text-gray">5 months ago</div>
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      <a target="_blank" rel="nofollow" href="https://www.reuters.com/business/healthcare-pharmaceuticals/spyre-says-bowel-disease-drug-cuts-inflammation-mid-stage-trial-2026-06-15/">Spyre says bowel disease drug cuts inflammation in mid-stage trial</a>
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        Spyre Therapeutics said on Monday its experimental bowel disease drug met the main goal of significantly ​reducing disease severity in a mid-stage trial.
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        <div class="me-2 text-gray">5 months ago</div>
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      <a target="_blank" rel="nofollow" href="https://www.globenewswire.com/news-release/2026/06/15/3311741/0/en/spyre-announces-potential-best-in-class-spy002-anti-tl1a-part-a-induction-results-from-skyline-trial-in-moderate-to-severe-ulcerative-colitis-patients.html">Spyre Announces Potential Best-in-Class SPY002 (anti-TL1A) Part A Induction Results from SKYLINE Trial in Moderate-to-Severe Ulcerative Colitis Patients</a>
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        SPY002 met its primary endpoint with a statistically significant reduction of 10.7 points (p
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