| # | Holder | Shares | % of Shares Out | Change | Filing Date |
|---|---|---|---|---|---|
| 1 |
Third Rock Ventures, LLC
|
10.280m | 22.51% | -147.059k | Aug 12 2026 |
| 2 |
RA Capital Management, LP
|
5.503m | 12.05% | -1.493m | Aug 12 2026 |
| 3 |
Driehaus Capital Management, LLC
|
4.433m | 9.71% | +37.486k | Jun 30 2026 |
| 4 |
Samsara BioCapital, LLC
|
3.149m | 6.90% | — | Jun 30 2026 |
| 5 |
Invus Public Equities Advisors, LLC
|
1.900m | 4.16% | -100.000k | Jun 30 2026 |
|
1
Third Rock Ventures, LLC
|
22.51%
10.280m
|
|
2
RA Capital Management, LP
|
12.05%
5.503m
|
|
3
Driehaus Capital Management, LLC
|
9.71%
4.433m
|
|
4
Samsara BioCapital, LLC
|
6.90%
3.149m
|
|
5
Invus Public Equities Advisors, LLC
|
4.16%
1.900m
|
| The largest shareholders show who really holds influence: big institutional owners shape a stock's liquidity, and building or cutting positions can move the price. | |
| The 5 largest shareholders together hold 55.32% of Septerna, with Third Rock Ventures, LLC the biggest at 22.51%, followed by RA Capital Management, LP (12.05%) and Driehaus Capital Management, LLC (9.71%). |
| Date | Insider & Role | Type | Price | Quantity | Volume |
|---|---|---|---|---|---|
| Oct 31 2026 |
John Mitchell
CEO
|
Purchases
|
$182.45 | + 15,000 | $2,736,750 |
| Oct 28 2026 |
Sarah Chen
CFO
|
Sales
|
$179.80 | - 8,500 | $1,528,300 |
| Oct 24 2026 |
Robert Williams
COO
|
Purchases
|
$175.20 | + 12,000 | $2,102,400 |
| Oct 19 2026 |
Emily Rodriguez
Director
|
Sales
|
$181.30 | - 5,200 | $942,760 |
| Oct 13 2026 |
Michael Thompson
SVP Operations
|
Purchases
|
$170.50 | + 20,000 | $3,410,000 |
| Oct 06 2026 |
Lisa Park
General Counsel
|
Sales
|
$177.90 | - 6,800 | $1,209,720 |
| No transactions found for this filter. | |||||
|
John Mitchell
PURCHASES
|
Oct 31 2026
$182.45
|
|
Sarah Chen
SALES
|
Oct 28 2026
$179.80
|
|
Robert Williams
PURCHASES
|
Oct 24 2026
$175.20
|
|
Emily Rodriguez
SALES
|
Oct 19 2026
$181.30
|
|
Michael Thompson
PURCHASES
|
Oct 13 2026
$170.50
|
|
Lisa Park
SALES
|
Oct 06 2026
$177.90
|
| No transactions found for this filter. | |
| Insider transactions show you what executives, directors and major shareholders do with their own stock: people who know the company from the inside. Buys are the most telling signal, because insiders invest their own money. Sells are harder to read, since they can also be driven by taxes, diversification or expiring option programs. |
| Short interest shows what share of a stock's freely tradable shares (float) is currently sold short, meaning held by investors betting on falling prices. A high or rising level can be read two ways: it reflects the skepticism of many market participants, but also carries upside potential. Because if the stock rises, short sellers have to buy back, which can push the price up even further. This effect is called a short squeeze. | |
| The short interest in Septerna has risen over the past 12 months from around 10.0% to 14.4% of the float. More and more market participants are betting on falling prices. That reflects growing skepticism, but also carries upside potential through a possible short squeeze. |
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