$71.55
2.45% day before yesterday
Nasdaq, Nov 14, 10:00 pm CET
ISIN
US4622221004
Symbol
IONS

Ionis Pharmaceuticals, Inc. Target price 2025 - Analyst rating & recommendation

Ionis Pharmaceuticals, Inc. Classifications & Recommendation:

Buy
77%
Hold
23%

Ionis Pharmaceuticals, Inc. Price Target

Target Price $79.56
Price $71.55
Potential
Number of Estimates 26
26 Analysts have issued a price target Ionis Pharmaceuticals, Inc. 2026 . The average Ionis Pharmaceuticals, Inc. target price is $79.56. This is higher than the current stock price. The highest price target is , the lowest is .
A rating was issued by 31 analysts: 24 Analysts recommend Ionis Pharmaceuticals, Inc. to buy, 7 to hold and 0 to sell.
Analysts don't have a crystal ball either, but they do represent the opinion of the market quite well. You should not take the price potential and the ratings as a recommendation to act. Rather, they serve as an additional building block for your own opinion or stock analysis.
Analyst Estimates: Analysts believe that the Ionis Pharmaceuticals, Inc. stock has an average upside potential 2026 of . Most analysts recommend the Ionis Pharmaceuticals, Inc. stock at Purchase.

Sales and Margin forecast 2025, 2026 to 2032

Create a premium account to unlock analyst estimates. Learn more

Quarter Annually
Dec '24 2025
Estimates
Revenue Million $ 705.14 902.28
10.48% 27.96%
EBITDA Margin -65.68% -41.33%
61.22% 37.07%
Net Margin -64.37% -42.13%
38.42% 34.55%

28 Analysts have issued a sales forecast Ionis Pharmaceuticals, Inc. 2025 . The average Ionis Pharmaceuticals, Inc. sales estimate is

$902m
Unlock
. This is
6.69% lower
Unlock
than the revenue of the last 12 months(TTM). The highest sales forecast is
$959m 0.86%
Unlock
, the lowest is
$819m 15.27%
Unlock
.

This results in the following potential growth metrics:

Revenue Estimates

2024 $705m 10.48%
2025
$902m 27.96%
Unlock
2026
$923m 2.33%
Unlock
2027
$1.4b 50.87%
Unlock
2028
$1.9b 33.67%
Unlock
2029
$2.5b 34.32%
Unlock
2030
$3.2b 26.63%
Unlock
2031
$3.7b 16.67%
Unlock
2032
$4.2b 14.97%
Unlock

12 Analysts have issued an Ionis Pharmaceuticals, Inc. EBITDA forecast 2025. The average Ionis Pharmaceuticals, Inc. EBITDA estimate is

$-373m
Unlock
. This is
35.96% lower
Unlock
than the EBITDA of the last 12 months(TTM). The highest EBITDA forecast is
$-293m 6.70%
Unlock
, the lowest is
$-407m 48.52%
Unlock
.

This results in the following potential growth metrics and future EBITDA Margins:

EBITDA Estimates

2024 $-463m 44.33%
2025
$-373m 19.48%
Unlock
2026
$-508m 36.24%
Unlock
2027
$-280m 44.88%
Unlock

EBITDA Margin

2024 -65.68% 61.22%
2025
-41.33% 37.07%
Unlock
2026
-55.02% 33.12%
Unlock
2027
-20.10% 63.47%
Unlock

28 Ionis Pharmaceuticals, Inc. Analysts have issued a net profit forecast 2025. The average Ionis Pharmaceuticals, Inc. net profit estimate is

$-380m
Unlock
. This is
48.28% lower
Unlock
than the net profit for the last 12 months(TTM). The highest net profit forecast is
$-156m 39.28%
Unlock
, the lowest is
$-442m 72.49%
Unlock
.

This results in the following potential growth metrics and future Net Margins:

Net Profit Estimates

2024 $-454m 23.92%
2025
$-380m 16.26%
Unlock
2026
$-493m 29.70%
Unlock
2027
$-213m 56.81%
Unlock
2028
$238m 211.81%
Unlock
2029
$639m 168.24%
Unlock
2030
$980m 53.47%
Unlock
2031
$1.2b 23.83%
Unlock
2032
$1.5b 21.58%
Unlock

Net Margin

2024 -64.37% 38.42%
2025
-42.13% 34.55%
Unlock
2026
-53.39% 26.73%
Unlock
2027
-15.28% 71.38%
Unlock
2028
12.78% 183.64%
Unlock
2029
25.53% 99.77%
Unlock
2030
30.94% 21.19%
Unlock
2031
32.84% 6.14%
Unlock
2032
34.73% 5.76%
Unlock

Earnings per share, P/E ratio and EV/sales Estimates 2025, 2026 to 2032

Create a premium account to unlock analyst estimates. Learn more

Quarter Annually
Dec '24 2025
Estimates
Earnings Per Share $ -3.04 -2.36
18.75% 22.37%
P/E negative
EV/Sales 11.72

28 Analysts have issued a Ionis Pharmaceuticals, Inc. forecast for earnings per share. The average Ionis Pharmaceuticals, Inc. EPS is

$-2.36
Unlock
. This is
47.50% lower
Unlock
than earnings per share in the financial year 2024. The highest EPS forecast is
$-0.97 39.38%
Unlock
, the lowest is
$-2.74 71.25%
Unlock
.

This results in the following potential growth metrics and future valuations:

Earnings Per Share

2024 $-3.04 18.75%
2025
$-2.36 22.37%
Unlock
2026
$-3.06 29.66%
Unlock
2027
$-1.32 56.86%
Unlock
2028
$1.48 212.12%
Unlock
2029
$3.96 167.57%
Unlock
2030
$6.08 53.54%
Unlock
2031
$7.53 23.85%
Unlock
2032
$9.16 21.65%
Unlock

P/E ratio

Current -44.72 175.00%
2025
-30.33 32.18%
Unlock
2026
-23.39 22.88%
Unlock
2027
-54.15 131.51%
Unlock
2028
48.43 189.44%
Unlock
2029
18.06 62.71%
Unlock
2030
11.76 34.88%
Unlock
2031
9.50 19.22%
Unlock
2032
7.81 17.79%
Unlock

Based on analysts' sales estimates for 2025, the Ionis Pharmaceuticals, Inc. stock is valued at an EV/Sales of

11.72
Unlock
and an P/S ratio of
12.84
Unlock
.

This results in the following potential growth metrics and future valuations:

EV/Sales

Current 10.94 76.45%
2025
11.72 7.14%
Unlock
2026
11.45 2.28%
Unlock
2027
7.59 33.72%
Unlock
2028
5.68 25.19%
Unlock
2029
4.23 25.55%
Unlock
2030
3.34 21.03%
Unlock
2031
2.86 14.29%
Unlock
2032
2.49 13.02%
Unlock

P/S ratio

Current 11.99 55.54%
2025
12.84 7.17%
Unlock
2026
12.55 2.28%
Unlock
2027
8.32 33.72%
Unlock
2028
6.22 25.19%
Unlock
2029
4.63 25.55%
Unlock
2030
3.66 21.03%
Unlock
2031
3.14 14.29%
Unlock
2032
2.73 13.02%
Unlock

Current Ionis Pharmaceuticals, Inc. Upgrades & Downgrades

Create a Premium account to unlock Upgrades/Downgrades. Learn more
Analyst Rating Action Date
HC Wainwright & Co.
Locked
Locked
Locked Nov 10 2025
Piper Sandler
Locked
Locked
Locked Nov 04 2025
HC Wainwright & Co.
Locked
Locked
Locked Oct 30 2025
Needham
Locked
Locked
Locked Oct 30 2025
Morgan Stanley
Locked
Locked
Locked Oct 30 2025
Barclays
Locked
Locked
Locked Oct 30 2025
Raymond James
Locked
Locked
Locked Oct 30 2025
Analyst Rating Date
Locked
HC Wainwright & Co.:
Locked
Locked
Nov 10 2025
Locked
Piper Sandler:
Locked
Locked
Nov 04 2025
Locked
HC Wainwright & Co.:
Locked
Locked
Oct 30 2025
Locked
Needham:
Locked
Locked
Oct 30 2025
Locked
Morgan Stanley:
Locked
Locked
Oct 30 2025
Locked
Barclays:
Locked
Locked
Oct 30 2025
Locked
Raymond James:
Locked
Locked
Oct 30 2025

Register for Free

StocksGuide is the ultimate tool for easily finding, analyzing and tracking stocks. Learn from successful investors and make informed investment decisions. We empower you to become a confident, independent investor.

The Apple stock at a glance with charts, current key metrics, news and stock analyses.
The Best Dividend Stocks in the Dividend Top Scorer list.
Stock Analyses of the Best Stocks Worldwide.
Start building wealth today