$1.13
1.35%
Nasdaq, Sep 17, 11:55 am EDT. Market open.
ISIN
US84833T1034
Symbol
SPRO

Spero Therapeutics, Inc. Target price 2026 - Analyst rating & recommendation

Spero Therapeutics, Inc. Classifications & Recommendation

Hold
50%
Sell
50%

Spero Therapeutics, Inc. Price Target

Target Price $4.08
Price $1.11
Potential
Number of Estimates 3
3 Analysts have issued a price target Spero Therapeutics, Inc. 2027 . The average Spero Therapeutics, Inc. target price is $4.08. This is higher than the current stock price. The highest price target is , the lowest is .
A rating was issued by 6 analysts: 0 Analysts recommend Spero Therapeutics, Inc. to buy, 3 to hold and 3 to sell.
Analysts don't have a crystal ball either, but they do represent the opinion of the market quite well. You should not take the price potential and the ratings as a recommendation to act. Rather, they serve as an additional building block for your own opinion or stock analysis.
Analyst Estimates: Analysts believe that the Spero Therapeutics, Inc. stock has an average upside potential 2027 of . Most analysts recommend the Spero Therapeutics, Inc. stock at Sell or hold.

Sales and Margin forecast 2026, 2027 & 2028

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Select at least one metric to display the chart.


Dec '25 2026
Estimates
Revenue Million $ 66.80 0.82
39.22% 98.78%
Net Margin 12.83% -2,107.94%
108.98% 16,530.62%

3 Analysts have issued a sales forecast Spero Therapeutics, Inc. 2026 . The average Spero Therapeutics, Inc. sales estimate is

$816k
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. This is
98.26% lower
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than the revenue of the last 12 months(TTM). The highest sales forecast is
$840k 98.21%
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, the lowest is
$784k 98.33%
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.

This results in the following potential growth metrics:

Revenue Estimates

2025 $66.8m 39.22%
2026
$816k 98.78%
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2027
$3.3m 300.00%
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2028
$33.8m 934.38%
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3 Spero Therapeutics, Inc. Analysts have issued a net profit forecast 2026. The average Spero Therapeutics, Inc. net profit estimate is

$-17.2m
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. This is
333.06% lower
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than the net profit for the last 12 months(TTM). The highest net profit forecast is
$-16.5m 323.98%
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, the lowest is
$-17.7m 339.97%
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.

This results in the following potential growth metrics and future Net Margins:

Net Profit Estimates

2025 $8.6m 112.50%
2026
$-17.2m 300.70%
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2027
$39.7m 331.05%
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Net Margin

2025 12.83% 108.98%
2026
-2,107.94% 16,530.62%
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2027
1,217.52% 157.76%
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Earnings per share, P/E ratio and EV/sales Estimates 2026, 2027 & 2028

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Select at least one metric to display the chart.


Quarter Annually
Dec '25 2026
Estimates
Earnings Per Share $ 0.15 -0.30
111.81% 300.00%
P/E negative
EV/Sales 17.00

3 Analysts have issued a Spero Therapeutics, Inc. forecast for earnings per share. The average Spero Therapeutics, Inc. EPS is

$-0.30
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. This is
350.00% lower
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than earnings per share in the financial year 2025. The highest EPS forecast is
$-0.30 350.00%
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, the lowest is
$-0.28 333.33%
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.

This results in the following potential growth metrics and future valuations:

Earnings Per Share

2025 $0.15 111.81%
2026
$-0.30 300.00%
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2027
$0.68 326.67%
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P/E ratio

Current 9.25 562.50%
2026
-3.75 140.54%
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2027
1.62 143.20%
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Based on analysts' sales estimates for 2026, the Spero Therapeutics, Inc. stock is valued at an EV/Sales of

17.00
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and an P/S ratio of
79.22
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.

This results in the following potential growth metrics and future valuations:

EV/Sales

Current 0.30 80.77%
2026
17.00 5,565.83%
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2027
4.25 75.00%
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2028
0.41 90.33%
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P/S ratio

Current 1.38 37.51%
2026
79.22 5,659.89%
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2027
19.80 75.00%
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2028
1.91 90.33%
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Current Spero Therapeutics, Inc. Upgrades & Downgrades

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Analyst Rating Action Date
HC Wainwright & Co.
Locked
Locked
Locked Sep 14 2026
HC Wainwright & Co.
Locked
Locked
Locked Jan 30 2025
Evercore ISI Group
Locked
Locked
Locked Dec 20 2024
HC Wainwright & Co.
Locked
Locked
Locked Dec 02 2024
TD Cowen
Locked
Locked
Locked Nov 18 2024
Cantor Fitzgerald
Locked
Locked
Locked Nov 15 2024
HC Wainwright & Co.
Locked
Locked
Locked Nov 04 2024
Analyst Rating Date
Locked
HC Wainwright & Co.:
Locked
Locked
Sep 14 2026
Locked
HC Wainwright & Co.:
Locked
Locked
Jan 30 2025
Locked
Evercore ISI Group:
Locked
Locked
Dec 20 2024
Locked
HC Wainwright & Co.:
Locked
Locked
Dec 02 2024
Locked
TD Cowen:
Locked
Locked
Nov 18 2024
Locked
Cantor Fitzgerald:
Locked
Locked
Nov 15 2024
Locked
HC Wainwright & Co.:
Locked
Locked
Nov 04 2024

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