$42.69
1.26%
Nasdaq, Aug 22, 10:00 pm CET
ISIN
US4622221004
Symbol
IONS

Ionis Pharmaceuticals, Inc. Target price 2025 - Analyst rating & recommendation

Ionis Pharmaceuticals, Inc. Classifications & Recommendation:

Buy
73%
Hold
24%
Sell
3%

Ionis Pharmaceuticals, Inc. Price Target

Target Price $63.24
Price $42.69
Potential
Number of Estimates 28
28 Analysts have issued a price target Ionis Pharmaceuticals, Inc. 2026 . The average Ionis Pharmaceuticals, Inc. target price is $63.24. This is higher than the current stock price. The highest price target is , the lowest is .
A rating was issued by 33 analysts: 24 Analysts recommend Ionis Pharmaceuticals, Inc. to buy, 8 to hold and 1 to sell.
Analysts don't have a crystal ball either, but they do represent the opinion of the market quite well. You should not take the price potential and the ratings as a recommendation to act. Rather, they serve as an additional building block for your own opinion or stock analysis.
Analyst Estimates: Analysts believe that the Ionis Pharmaceuticals, Inc. stock has an average upside potential 2026 of . Most analysts recommend the Ionis Pharmaceuticals, Inc. stock at Purchase.

Sales and Margin forecast 2025, 2026 to 2032

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Quarter Annually
Dec '24 2025
Estimates
Revenue Million $ 705.14 876.52
10.48% 24.30%
EBITDA Margin -64.26% -45.45%
62.62% 29.27%
Net Margin -64.37% -46.67%
38.42% 27.50%

30 Analysts have issued a sales forecast Ionis Pharmaceuticals, Inc. 2025 . The average Ionis Pharmaceuticals, Inc. sales estimate is

$877m
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. This is
7.15% lower
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than the revenue of the last 12 months(TTM). The highest sales forecast is
$1,000m 5.90%
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, the lowest is
$821m 13.02%
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.

This results in the following potential growth metrics:

Revenue Estimates

2024 $705m 10.48%
2025
$877m 24.30%
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2026
$941m 7.39%
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2027
$1.3b 33.75%
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2028
$1.7b 32.41%
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2029
$2.3b 35.45%
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2030
$2.9b 29.05%
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2031
$3.2b 11.39%
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2032
$3.7b 14.82%
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13 Analysts have issued an Ionis Pharmaceuticals, Inc. EBITDA forecast 2025. The average Ionis Pharmaceuticals, Inc. EBITDA estimate is

$-398m
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. This is
62.67% lower
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than the EBITDA of the last 12 months(TTM). The highest EBITDA forecast is
$-292m 19.11%
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, the lowest is
$-448m 82.79%
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.

This results in the following potential growth metrics and future EBITDA Margins:

EBITDA Estimates

2024 $-453m 45.58%
2025
$-398m 12.07%
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2026
$-474m 18.86%
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2027
$-190m 59.90%
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EBITDA Margin

2024 -64.26% 62.62%
2025
-45.45% 29.27%
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2026
-50.31% 10.69%
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2027
-15.08% 70.03%
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30 Ionis Pharmaceuticals, Inc. Analysts have issued a net profit forecast 2025. The average Ionis Pharmaceuticals, Inc. net profit estimate is

$-409m
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. This is
52.52% lower
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than the net profit for the last 12 months(TTM). The highest net profit forecast is
$-239m 10.88%
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, the lowest is
$-455m 69.50%
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.

This results in the following potential growth metrics and future Net Margins:

Net Profit Estimates

2024 $-454m 23.92%
2025
$-409m 9.87%
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2026
$-468m 14.34%
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2027
$-286m 38.85%
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2028
$195m 168.03%
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2029
$554m 184.58%
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2030
$896m 61.73%
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2031
$1.0b 12.00%
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2032
$1.2b 22.61%
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Net Margin

2024 -64.37% 38.42%
2025
-46.67% 27.50%
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2026
-49.69% 6.47%
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2027
-22.72% 54.28%
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2028
11.67% 151.36%
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2029
24.52% 110.11%
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2030
30.73% 25.33%
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2031
30.90% 0.55%
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2032
33.00% 6.80%
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Earnings per share, P/E ratio and EV/sales Estimates 2025, 2026 to 2032

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Quarter Annually
Dec '24 2025
Estimates
Earnings Per Share $ -3.04 -2.57
18.75% 15.46%
P/E negative
EV/Sales 6.58

30 Analysts have issued a Ionis Pharmaceuticals, Inc. forecast for earnings per share. The average Ionis Pharmaceuticals, Inc. EPS is

$-2.57
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. This is
74.83% lower
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than earnings per share in the financial year 2024. The highest EPS forecast is
$-1.50 2.04%
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, the lowest is
$-2.86 94.56%
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.

This results in the following potential growth metrics and future valuations:

Earnings Per Share

2024 $-3.04 18.75%
2025
$-2.57 15.46%
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2026
$-2.94 14.40%
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2027
$-1.80 38.78%
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2028
$1.22 167.78%
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2029
$3.48 185.25%
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2030
$5.63 61.78%
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2031
$6.30 11.90%
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2032
$7.72 22.54%
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P/E ratio

Current -29.04 56.27%
2025
-16.61 42.80%
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2026
-14.53 12.52%
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2027
-23.76 63.52%
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2028
34.93 247.01%
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2029
12.27 64.87%
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2030
7.59 38.14%
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2031
6.78 10.67%
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2032
5.53 18.44%
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Based on analysts' sales estimates for 2025, the Ionis Pharmaceuticals, Inc. stock is valued at an EV/Sales of

and an P/S ratio of .

This results in the following potential growth metrics and future valuations:

EV/Sales

Current 6.11 17.10%
2025
6.58 7.74%
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2026
6.13 6.88%
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2027
4.58 25.23%
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2028
3.46 24.48%
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2029
2.56 26.17%
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2030
1.98 22.51%
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2031
1.78 10.23%
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2032
1.55 12.91%
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P/S ratio

Current 7.21 13.69%
2025
7.76 7.70%
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2026
7.23 6.88%
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2027
5.40 25.23%
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2028
4.08 24.48%
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2029
3.01 26.17%
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2030
2.34 22.51%
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2031
2.10 10.23%
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2032
1.83 12.90%
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Current Ionis Pharmaceuticals, Inc. Upgrades & Downgrades

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Analyst Rating Action Date
Barclays
Locked
Locked
Locked Aug 22 2025
Piper Sandler
Locked
Locked
Locked Aug 22 2025
Citigroup
Locked
Locked
Locked Aug 22 2025
Wells Fargo
Locked
Locked
Locked Aug 22 2025
HC Wainwright & Co.
Locked
Locked
Locked Aug 22 2025
UBS
Locked
Locked
Locked Aug 12 2025
Morgan Stanley
Locked
Locked
Locked Jul 31 2025
Analyst Rating Date
Locked
Barclays:
Locked
Locked
Aug 22 2025
Locked
Piper Sandler:
Locked
Locked
Aug 22 2025
Locked
Citigroup:
Locked
Locked
Aug 22 2025
Locked
Wells Fargo:
Locked
Locked
Aug 22 2025
Locked
HC Wainwright & Co.:
Locked
Locked
Aug 22 2025
Locked
UBS:
Locked
Locked
Aug 12 2025
Locked
Morgan Stanley:
Locked
Locked
Jul 31 2025

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