$45.09
1.45%
Nasdaq, Sep 21, 03:49 pm EDT. Closed.
ISIN
US4622221004
Symbol
IONS

Ionis Pharmaceuticals, Inc. Target price 2026 - Analyst rating & recommendation

Ionis Pharmaceuticals, Inc. Classifications & Recommendation

Buy
78%
Hold
22%

Ionis Pharmaceuticals, Inc. Price Target

Target Price $91.80
Price $44.44
Potential
Number of Estimates 25
25 Analysts have issued a price target Ionis Pharmaceuticals, Inc. 2027 . The average Ionis Pharmaceuticals, Inc. target price is $91.80. This is higher than the current stock price. The highest price target is , the lowest is .
A rating was issued by 32 analysts: 25 Analysts recommend Ionis Pharmaceuticals, Inc. to buy, 7 to hold and 0 to sell.
Analysts don't have a crystal ball either, but they do represent the opinion of the market quite well. You should not take the price potential and the ratings as a recommendation to act. Rather, they serve as an additional building block for your own opinion or stock analysis.
Analyst Estimates: Analysts believe that the Ionis Pharmaceuticals, Inc. stock has an average upside potential 2027 of . Most analysts recommend the Ionis Pharmaceuticals, Inc. stock at Purchase.

Sales and Margin forecast 2026, 2027 to 2033

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Select at least one metric to display the chart.


Quarter Annually
Dec '25 2026
Estimates
Revenue Million $ 943.71 937.09
33.83% 0.70%
EBITDA Margin -39.13% -66.58%
40.43% 70.17%
Net Margin -40.41% -64.07%
37.22% 58.53%

28 Analysts have issued a sales forecast Ionis Pharmaceuticals, Inc. 2026 . The average Ionis Pharmaceuticals, Inc. sales estimate is

$937m
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. This is
7.21% higher
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than the revenue of the last 12 months(TTM). The highest sales forecast is
$1.0b 18.98%
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, the lowest is
$767m 12.21%
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.

This results in the following potential growth metrics:

Revenue Estimates

2025 $944m 33.83%
2026
$937m 0.70%
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2027
$1.4b 51.43%
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2028
$2.0b 42.00%
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2029
$3.1b 52.70%
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2030
$3.9b 26.58%
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2031
$4.6b 18.23%
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2032
$5.3b 15.64%
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2033
$5.9b 10.40%
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12 Analysts have issued an Ionis Pharmaceuticals, Inc. EBITDA forecast 2026. The average Ionis Pharmaceuticals, Inc. EBITDA estimate is

$-624m
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. This is
7.67% lower
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than the EBITDA of the last 12 months(TTM). The highest EBITDA forecast is
$-607m 4.80%
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, the lowest is
$-617m 6.54%
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.

This results in the following potential growth metrics and future EBITDA Margins:

EBITDA Estimates

2025 $-369m 20.27%
2026
$-624m 68.97%
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2027
$-319m 48.86%
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2028
$59.0m 118.49%
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EBITDA Margin

2025 -39.13% 40.43%
2026
-66.58% 70.17%
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2027
-22.49% 66.22%
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2028
2.93% 113.03%
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27 Ionis Pharmaceuticals, Inc. Analysts have issued a net profit forecast 2026. The average Ionis Pharmaceuticals, Inc. net profit estimate is

$-600m
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. This is
6.23% lower
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than the net profit for the last 12 months(TTM). The highest net profit forecast is
$-524m 7.37%
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, the lowest is
$-660m 16.75%
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.

This results in the following potential growth metrics and future Net Margins:

Net Profit Estimates

2025 $-381m 15.97%
2026
$-600m 57.42%
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2027
$-363m 39.54%
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2028
$60.6m 116.69%
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2029
$920m 1,419.26%
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2030
$1.4b 49.29%
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2031
$1.7b 25.36%
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2032
$2.1b 20.94%
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2033
$2.2b 7.57%
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Net Margin

2025 -40.41% 37.22%
2026
-64.07% 58.53%
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2027
-25.58% 60.07%
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2028
3.01% 111.77%
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2029
29.91% 893.69%
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2030
35.28% 17.95%
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2031
37.40% 6.01%
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2032
39.12% 4.60%
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2033
38.12% 2.56%
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Earnings per share, P/E ratio and EV/sales Estimates 2026, 2027 to 2033

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Select at least one metric to display the chart.


Quarter Annually
Dec '25 2026
Estimates
Earnings Per Share $ -2.38 -3.62
21.71% 52.10%
P/E negative
EV/Sales 7.73

27 Analysts have issued a Ionis Pharmaceuticals, Inc. forecast for earnings per share. The average Ionis Pharmaceuticals, Inc. EPS is

$-3.62
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. This is
6.16% lower
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than earnings per share in the financial year 2025. The highest EPS forecast is
$-3.16 7.33%
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, the lowest is
$-3.98 16.72%
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.

This results in the following potential growth metrics and future valuations:

Earnings Per Share

2025 $-2.38 21.71%
2026
$-3.62 52.10%
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2027
$-2.19 39.50%
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2028
$0.37 116.89%
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2029
$5.56 1,402.70%
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2030
$8.30 49.28%
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2031
$10.40 25.30%
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2032
$12.58 20.96%
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2033
$13.53 7.55%
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P/E ratio

Current -13.03 69.67%
2026
-12.26 5.93%
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2027
-20.28 65.42%
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2028
121.51 699.16%
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2029
8.00 93.42%
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2030
5.36 33.00%
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2031
4.27 20.34%
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2032
3.53 17.33%
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2033
3.28 7.08%
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Based on analysts' sales estimates for 2026, the Ionis Pharmaceuticals, Inc. stock is valued at an EV/Sales of

and an P/S ratio of .

This results in the following potential growth metrics and future valuations:

EV/Sales

Current 8.29 13.38%
2026
7.73 6.75%
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2027
5.11 33.96%
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2028
3.60 29.58%
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2029
2.35 34.52%
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2030
1.86 21.00%
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2031
1.57 15.42%
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2032
1.36 13.52%
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2033
1.23 9.42%
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P/S ratio

Current 8.45 20.77%
2026
7.88 6.72%
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2027
5.20 33.96%
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2028
3.67 29.58%
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2029
2.40 34.51%
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2030
1.90 21.00%
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2031
1.60 15.42%
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2032
1.39 13.52%
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2033
1.26 9.42%
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Current Ionis Pharmaceuticals, Inc. Upgrades & Downgrades

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Analyst Rating Action Date
Guggenheim
Locked
Locked
Locked Sep 15 2026
Barclays
Locked
Locked
Locked Sep 09 2026
BMO Capital
Locked
Locked
Locked Sep 08 2026
Canaccord Genuity
Locked
Locked
Locked Sep 08 2026
Goldman Sachs
Locked
Locked
Locked Sep 08 2026
HC Wainwright & Co.
Locked
Locked
Locked Sep 08 2026
Morgan Stanley
Locked
Locked
Locked Sep 08 2026
Analyst Rating Date
Locked
Guggenheim:
Locked
Locked
Sep 15 2026
Locked
Barclays:
Locked
Locked
Sep 09 2026
Locked
BMO Capital:
Locked
Locked
Sep 08 2026
Locked
Canaccord Genuity:
Locked
Locked
Sep 08 2026
Locked
Goldman Sachs:
Locked
Locked
Sep 08 2026
Locked
HC Wainwright & Co.:
Locked
Locked
Sep 08 2026
Locked
Morgan Stanley:
Locked
Locked
Sep 08 2026

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