$5.16
0.19%
Nasdaq, Sep 25, 12:14 pm EDT. Market open.
ISIN
US91678A1079
Symbol
UPB

Upstream Bio Target price 2026 - Analyst rating & recommendation

Upstream Bio Classifications & Recommendation

Buy
77%
Hold
23%

Upstream Bio Price Target

Target Price $31.11
Price $5.17
Potential
Number of Estimates 8
8 Analysts have issued a price target Upstream Bio 2027 . The average Upstream Bio target price is $31.11. This is higher than the current stock price. The highest price target is
$78.75 1,423.21%
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, the lowest is .
A rating was issued by 13 analysts: 10 Analysts recommend Upstream Bio to buy, 3 to hold and 0 to sell.
Analysts don't have a crystal ball either, but they do represent the opinion of the market quite well. You should not take the price potential and the ratings as a recommendation to act. Rather, they serve as an additional building block for your own opinion or stock analysis.
Analyst Estimates: Analysts believe that the Upstream Bio stock has an average upside potential 2027 of . Most analysts recommend the Upstream Bio stock at Purchase.

Sales and Margin forecast 2026, 2027 to 2033

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Select at least one metric to display the chart.


Quarter Annually
Dec '25 2026
Estimates
Revenue Million $ 2.85 2.68
20.25% 5.89%
EBITDA Margin -5,620.00% -6,477.26%
71.46% 15.25%
Net Margin -5,032.98% -5,990.17%
56.13% 19.02%

8 Analysts have issued a sales forecast Upstream Bio 2026 . The average Upstream Bio sales estimate is

$2.7m
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. This is
15.13% lower
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than the revenue of the last 12 months(TTM). The highest sales forecast is
$3.6m 13.32%
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, the lowest is
$1.8m 44.18%
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.

This results in the following potential growth metrics:

Revenue Estimates

2025 $2.9m 20.25%
2026
$2.7m 5.89%
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2027
$1.4m 48.66%
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2028
$3.5m 154.61%
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2029
$8.5m 142.30%
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2030
$74.7m 779.53%
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2031
$239m 219.74%
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2032
$456m 90.72%
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2033
$839m 84.09%
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2 Analysts have issued an Upstream Bio EBITDA forecast 2026. The average Upstream Bio EBITDA estimate is

$-174m
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. This is
2.32% lower
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than the EBITDA of the last 12 months(TTM). The highest EBITDA forecast is
$-181m 6.37%
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, the lowest is
$-169m 0.72%
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.

This results in the following potential growth metrics and future EBITDA Margins:

EBITDA Estimates

2025 $-160m 106.19%
2026
$-174m 8.46%
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2027
$-217m 25.00%
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2028
$-238m 9.77%
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EBITDA Margin

2025 -5,620.00% 71.46%
2026
-6,477.26% 15.25%
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2027
-15,769.79% 143.46%
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2028
-6,798.63% 56.89%
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10 Upstream Bio Analysts have issued a net profit forecast 2026. The average Upstream Bio net profit estimate is

$-161m
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. This is
2.66% lower
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than the net profit for the last 12 months(TTM). The highest net profit forecast is
$-125m 20.26%
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, the lowest is
$-175m 11.94%
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.

This results in the following potential growth metrics and future Net Margins:

Net Profit Estimates

2025 $-143m 87.75%
2026
$-161m 12.01%
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2027
$-153m 4.64%
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2028
$-161m 5.31%
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2029
$-191m 18.12%
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2030
$-168m 11.75%
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2031
$-104m 38.29%
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2032
$46.9m 145.17%
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2033
$208m 343.66%
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Net Margin

2025 -5,032.98% 56.13%
2026
-5,990.17% 19.02%
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2027
-11,126.49% 85.75%
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2028
-4,601.92% 58.64%
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2029
-2,243.31% 51.25%
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2030
-225.07% 89.97%
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2031
-43.44% 80.70%
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2032
10.29% 123.69%
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2033
24.80% 141.01%
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Earnings per share, P/E ratio and EV/sales Estimates 2026, 2027 to 2033

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Select at least one metric to display the chart.


Quarter Annually
Dec '25 2026
Estimates
Earnings Per Share $ -2.66 -2.93
78.52% 10.15%
P/E negative
EV/Sales 8.15

10 Analysts have issued a Upstream Bio forecast for earnings per share. The average Upstream Bio EPS is

$-2.93
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. This is
1.38% lower
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than earnings per share in the financial year 2025. The highest EPS forecast is
$-2.28 21.11%
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, the lowest is
$-3.20 10.73%
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.

This results in the following potential growth metrics and future valuations:

Earnings Per Share

2025 $-2.66 78.52%
2026
$-2.93 10.15%
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2027
$-2.80 4.44%
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2028
$-2.95 5.36%
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2029
$-3.48 17.97%
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2030
$-3.07 11.78%
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2031
$-1.89 38.44%
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2032
$0.86 145.50%
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2033
$3.80 341.86%
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P/E ratio

Current -1.79 77.72%
2026
-1.76 1.62%
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2027
-1.85 5.11%
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2028
-1.76 4.86%
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2029
-1.49 15.34%
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2030
-1.68 12.75%
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2031
-2.73 62.50%
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2032
6.04 321.25%
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2033
1.36 77.48%
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Based on analysts' sales estimates for 2026, the Upstream Bio stock is valued at an EV/Sales of

and an P/S ratio of
105.58
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.

This results in the following potential growth metrics and future valuations:

EV/Sales

Current 6.92 96.15%
2026
8.15 17.78%
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2027
15.88 94.77%
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2028
6.24 60.72%
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2029
2.57 58.73%
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2030
0.29 88.63%
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2031
0.09 68.73%
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2032
0.05 47.54%
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2033
0.03 45.63%
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P/S ratio

Current 89.61 72.40%
2026
105.58 17.82%
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2027
205.64 94.77%
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2028
80.77 60.72%
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2029
33.33 58.73%
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2030
3.79 88.63%
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2031
1.19 68.73%
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2032
0.62 47.57%
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2033
0.34 45.68%
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Current Upstream Bio Upgrades & Downgrades

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Analyst Rating Action Date
HC Wainwright & Co.
Locked
➜
Locked
Locked Sep 02 2026
JP Morgan
Locked
➜
Locked
Locked Aug 14 2026
Truist Securities
Locked
➜
Locked
Locked Aug 12 2026
JP Morgan
Locked
➜
Locked
Locked Jun 12 2026
HC Wainwright & Co.
Locked
➜
Locked
Locked Jun 03 2026
Mizuho
Locked
➜
Locked
Locked May 14 2026
Evercore ISI Group
Locked
➜
Locked
Locked Mar 27 2026
Analyst Rating Date
Locked
HC Wainwright & Co.:
Locked
➜
Locked
Sep 02 2026
Locked
JP Morgan:
Locked
➜
Locked
Aug 14 2026
Locked
Truist Securities:
Locked
➜
Locked
Aug 12 2026
Locked
JP Morgan:
Locked
➜
Locked
Jun 12 2026
Locked
HC Wainwright & Co.:
Locked
➜
Locked
Jun 03 2026
Locked
Mizuho:
Locked
➜
Locked
May 14 2026
Locked
Evercore ISI Group:
Locked
➜
Locked
Mar 27 2026

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